Insulin‐like growth factor I supports differentiation of cultured osteoblast‐like cells

FEBS Letters

Schmid, C.¹  Froesch, E.R.¹  Steiner, T.¹ 

[1] Metabolic Unit, University Hospital, CH-8091 Zürich, Switzerland

关键词: Rat calvaria cell;    Osteoblast differentiation;    Alkaline phosphatase;    Insulin-like growth factor I;   

DOI  :  10.1016/0014-5793(84)81015-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rat calvaria cells grown in culture for one week had properties of osteoblasts: a high content in alkaline phosphatase and a marked cyclic AMP response to parathyroid hormone (PTH). In short-term experiments, insulin-like growth factor I (IGFI) stimulated the incorporation of (¹⁴C]glucose into glycogen. When IGF I was present in the medium during 6 days the cell number increased slightly and there was a substantial, disproportionate rise in alkaline phosphatase activity of the cultures. Thus, IGFI stimulates growth, and in addition, and in contrast to other growth factors, mainly enhances differentiation of osteoblasts.

【 授权许可】

Unknown