Inhibition of testosterone biosynthesis by ethanol: relation to the pregnenolone‐to‐testosterone pathway

FEBS Letters

Ylikahri, R.H.¹  Leinonen, P.³  Widenius, T.V.¹  Eriksson, C.J.P.¹  Härkönei, M.² 

[1] Research Laboratories of the Finnish State Alcohol Company, AIko Ltd, POB 350, SF-00101 Helsinki 10, Finland;Department of Clinical Chemistry, University of Helsinki, SF-00290 Helsinki 29, Finland;Department of Clinical Chemistry, University of Oulu, SF-90220 Oulu 22, Finland

关键词: Rat;    Testis;    Steroidogenesis;    Testosterone synthesis;    Ethanol;    4-Methylpyrazole;   

DOI  :  10.1016/0014-5793(84)81121-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The concentrations of metabolites in the pregnenolone → testosterone pathway were determined in freezestopped testes in control rats and during ethanol intoxication (2 h after injection of 1.5 body wt). Ethanol lowered the mean testicular concentrations of testosterone (by 63–74%), androstenedione (49–81%), 17-hydroxyprogesterone (60–76%), progesterone (29–67%) and pregnenolone (12–25%). 4-Methylpyrazole had no effect on the ethanol-induced changes. The present results reveal no inhibition at the 17-hydroxyprogesterone → androstenedione → testosterone steps, but do not exclude inhibition before the step yielding pregnenolone and at the pregnenolone → progesterone → 17-hydroxyprogesterone steps.

【 授权许可】

Unknown