Atrial pronatriodilatin: a precursor for natriuretic factor and cardiodilatin

FEBS Letters

Garcia, R.²  Lazure, C.¹  Cantin, M.²  Chrétien, M.¹  Thibault, G.²  Genest, J.²  Seidah, N.G.¹ 

[1] Laboratories of Biochemical and Molecular Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montréal, H2W 1R7 Canada;MRC Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montréal, H2W 1R7 Canada

关键词: Pronatriodilatin Cardiodilatin Amino acid sequence Precusor;   

DOI  :  10.1016/0014-5793(84)80878-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Numerous peptides isolated from rat heart atria, including two containing 33 and 73 amino acids, were isolated and shown to exhibit natriuretic activities. Here, we describe the purification and partial amino acid sequence of a 106-residue peptide containing the previously sequenced 33- and 73-amino-acid ANF peptides. The determined sequence is a novel one and is not significantly homologous to any known protein or segment thereof. In fact, this sequence shows significant homology only to another novel partial sequence obtained from sequence analysis of a porcine peptide, called cardiodilatin, also found in heart atria. This relationship is taken as evidence that ANF and cardiodilatin are part of the same precursor molecule which would contain at the very least 126 amino acids.

【 授权许可】

Unknown