Inhibition of synaptosomal 5‐[3H]hydroxytryptamine uptake by endogenous factor(s) in human blood

FEBS Letters

Paul, Steven M.¹  Angel, Itzchak¹ 

[1] Clinical Neuroscience Branch, NIMH, National Institutes of Health, Bethesda, MD 20205, USA

关键词: 5-Hydroxytryptamine uptake;    Plasma factor;    Synaptosome;    Imipramine;    Endogenous modulator;   

DOI  :  10.1016/0014-5793(84)80504-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The inhibition of 5-[³H] hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (M _r < 10000), and heat stable factor(s) were found to inhibit 5-[³H] hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.

【 授权许可】

Unknown