The mechanisms of the cyclic AMP‐dependent regulation of the enzymes of the 2′,5′‐oligoadenylate system

FEBS Letters

Kartasheva, O.N.¹  Turpaev, K.T.¹  Tunitskaya, V.L.¹  Itkes, A.V.¹  Kafiani, C.A.¹ 

[1] Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow 117984, USSR

关键词: Cyclic AMP;    2′;    5′-Oligoadenylate;    Cell regulation;   

DOI  :  10.1016/0014-5793(84)80467-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The cAMP-dependent induction of 2,5-oligoadenylate (2-5A) synthetase and cAMP-dependent inhibition of 2-5A phosphodiesterase are shown. Variations in activities of cAMP-dependent protein kinase and the enzymes of 2-5A metabolism in the cells deepening into the resting state were found to be compatible with the above finding. A scheme of coordinated action of cAMP and 2-5A is proposed.

【 授权许可】

Unknown