Structural similarities among concanavalin A, haptoglobin, and trypsin

FEBS Letters

Dobryszycka, Wanda¹  Przysiecki, Bernard¹ 

[1] Department of Biochemistry, Faculty of Pharmacy, Medical Academy, Szewska 38/39, 50-139 Wrocław, Poland

关键词: Concanavalin A;    Haptoglobin;    Trypsin;    Structural similarity;    Con A;    concanavalin A;    Hp;    haptoglobin;    Hp β;    haptoglobin β (heavy) chain;    BAEE;    benzoyl arginine ethyl ester;    TLCK;    L-1-chloro-3-p-tosylamido-7-amino-2-heptanone;    TPCK;    L-1-chloro-3-tosylamido-4-phenyl-2-butanone;   

DOI  :  10.1016/0014-5793(84)80464-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Comparison of the primary structure of concanavalin A with those of trypsin and β (heavy) chain of haptoglobin revealed a significant degree of chemical similarity. The amino acid sequence of concanavalin A was found to be 53.6% related to trypsin and haptoglobin. Certain analogy in the tertiary structure was shown by the use of thionine binding to the specific active site, characteristic for serine proteases.

【 授权许可】

Unknown