Sensitivity of thermoacidophilic archaebacteria to α‐sarcin

FEBS Letters

Sanz, J.L.¹  Amils, R.¹ 

[1]Centro de Biologia Molecular, CSIC and UAM, Canto Blanco, Madrid 34, Spain

关键词: Thermoacidophilic archaebacteria;    Protein synthesis inhibitor;    α-Sarcin;    Evolution;   

DOI  :  10.1016/0014-5793(84)80460-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The protein synthesis machinery of Sulfolobus solfataricus, a thermoacidophilic archaebacterium, is insensitive to most of the known antibiotics that interfere with elongation. α-Sarcin, a cytotoxic protein, inhibits protein synthesis on eukaryotic systems by cleaving a specific sequence of the large rRNA. α-Sarcin is capable of inhibiting protein synthesis on S. solfataricus producing a fragment under conditions similar to those which produce it in yeast ribosomes. This result suggests the presence on S. solfataricus of the sequence necessary for the enzymatic hydrolysis promoted by α-sarcin.

【 授权许可】

Unknown