Base‐specific ribonucleases potentially involved in heterogeneous nuclear RNA processing and poly(A) metabolism

FEBS Letters

Bachmann, Michael¹  Schröder, Heinz C.¹  Müller, Werner E.G.¹  Messer, Rudolf¹ 

[1] Institut für Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universität, Duesbergweg, 6500 Mainz, FRG

关键词: hnRNA processing;    Poly(A)+ mRNA;    Polyadenylation;    Splicing;    Ribonuclease;    snRNP;   

DOI  :  10.1016/0014-5793(84)80453-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Polyadenylation and splicing of heterogeneous nuclear RNA, two crucial steps in mRNA processing, are apparently enzymically mediated processes. This contribution summarizes the properties and the presumed functions of the known poly(A) catabolic enzymes (endoribonuclease IV and V, 2′,3′-exoribonuclease) as well as those of the pyrimidine-specific endoribonucleases associated with snRNP—hnRNP complexes (endoribonuclease VII, acidic pI 4.1 endoribonuclease and poly(U)-specific U1 snRNP-nuclease).

【 授权许可】

Unknown