A C‐terminal fragment of hemoglobin β‐chains in extracts of porcine upper intestine

FEBS Letters

Mutt, Viktor¹  Carlquist, Mats¹  Jörnvall, Hans¹ 

[1] Departments of Biochemistry II and Chemistry I, Karolinska Institutet, S-104 01 Stockholm, Sweden

关键词: Hemoglobin β-chain fragment;    Native protein fragment;    Cleavage site;    Signal sequence resemblance;    Intestinal extract;    Peptide isolation;   

DOI  :  10.1016/0014-5793(84)81362-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A 32-residue peptide has been isolated from extracts of porcine upper intestine. Amino acid sequence determination showed that the peptide is a fragment of hemoglobin, corresponding to the C-terminal part of the β-chain. The region in the β-chain which precedes the isolated fragment is hydrophobic (8 Leu/Val/Ile) and has no charges at 10 preceding positions. It therefore, to some extent, resembles the structure of ‘signal sequences’ which may suggest a specific cleavage site in hemoglobin β-chains.

【 授权许可】

Unknown