Biosynthesis of acyl‐specific glycerophospholipids in mammalian tissues

FEBS Letters

Infante, Juan P.¹ 

[1] Division of Nutritional Sciences, N-209 MVR, Cornell University, Ithaca, NY 14853, USA

关键词: Glycerophophodiester|Glycerophospholipid|Retinal phospholipid|Lung phosphatidylcholine|Fatty acid|Platelet-activating factor;    Pi;    orthophosphate;    GP;    glycerophosphate;    P-choline;    phosphorylcholine;    P-ethanolamine;    phosphorylethanolamine;    CDP-choline;    cytidinediphosphocholine;    CDP-ethanolamine;    cytidinediphosphoethanolamine;    CDP-serine;    cytidinediphosphoserine;    CDP-glycerol;    cytidinediphosphoglycerol;    CDP-DG;    cytidinediphosphodiglyceride;    GPC;    glycerophosphorylcholine;    GPE;    glycerophosphorylethanolamine;    GPG;    glycerophosphorylglycerol;    GPS;    glycerophosphorylserine;    PA;    phosphatidic acid;    PC;    phosphatidylcholine;    PE;    phosphatidylethanolamine;    PG;    phosphatidylglycerol;    PGP;    phosphatidylglycerophosphate;    PGGP;    phosphatidylglyceroglycerophosphate;    CL;    cardiolipin;    PI;    phosphatidylinositol;    PS;    phosphatidylserine;    DG;    sn-1;    2-diglyceride;    C18:0;    octadecanoate;    C18:2n—6 9;    12-octadecadienoate;    C18:3n—3;    9;    12;    15-octadecatrienoate;    C20:4n—6;    5;    8;    11;    14-eicosatetraenoate;    C22: 5n—6;    4;    7;    10;    13;    16-docosapentaenoate;    C22:6n—3;    4;    7;    10;    13;    16;    19-docosahexanoate;    SAM;    S-adenosylmethionine;    SAH;    S-adenosylhomocysteine;   

DOI  :  10.1016/0014-5793(84)81358-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A review of the literature concerning the synthesis of acyl-specific glycerophospholipids indicates that the known biosynthetic sequences cannot satisfactorily explain these specific acylations. New de novo and salvage pathways are proposed to account for the acyl composition of highly unsaturated and saturated glycerophospholipids. In these hypothetical pathways, de novo synthesized glycerophosphodiesters are postulated to be key intermediates to establish the specific acyl composition of the resulting glycerophospholipids, and to be integrated with the known cytidine pathways. A re-interpretation of the experimental literature in terms of these postulated pathways is provided, with some methods to test these proposed sequences.

【 授权许可】

Unknown