Inhibition of glucagon‐stimulated hepatic glycogenolysis by E‐series prostaglandins

FEBS Letters

Garrity, Maureen J.¹  Brass, Eric P.¹  Robertson, R.Paul¹ 

[1] Department of Medicine and Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA

关键词: PGE;    Prostaglandin;    Glucagon;    Glycogenolysis;    Hepatocyte;    PGE analog;   

DOI  :  10.1016/0014-5793(84)80336-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of E-series prostaglandins (PGE) on hepatic glucose metabolism is controversial. This study uses isolated rat hepatocytes and exogenously added PGE analogs or frequent native PGE additions (to compensate for hepatic PGE degradation) to define PGE's effect on hepatic glycogenolysis. 16,16-Dimethyl PGE₂, 15(S),15-methyl PGE₂, PGE₁ and PGE₂ all inhibit glucagon-stimulated glycogenolysis. It is concluded that E-series prostaglandins can act directly on the liver to inhibit glycogenolysis.

【 授权许可】

Unknown