Chronic ethanol administration decreases fatty acyl‐CoA desaturase activities in rat liver microsomes

FEBS Letters

Umeki, Shigenobu¹  Shiojiri, Hiroyuki¹  Nozawa, Yoshinori¹ 

[1] Department of Biochemistry, Gifu University School of Medicine, Tsukasamachi-40, Gifu, Japan

关键词: Chronic ethanol administration;    Fatty acyl-CoA desaturase;    Cyanide-sensitive factor;   

DOI  :  10.1016/0014-5793(84)80332-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Δ⁹-desaturase system in liver microsome from rats treated chronically with ethanol was studied. Stearoyl-CoA desaturase activity decreased by 80% and palmitoyl-CoA desaturase activity was not detectable in microsomes from ethanol-fed rats, while activities of electron transport components such as NADH-cytochrome c and NADH-ferricyanide reductases remained unchanged. However, chronic ethanol administration resulted in an adaptive induction of the activity of NADPH-cytochrome c reductase and the contents of cytochrome b ₅ and P-450. The activity of the terminal component (cyanide-sensitive factor; CSF) of the desaturase system was greatly depressed by ethanol treatment. The NADH/NAD ratio in microsomes of ethanol-fed rats increased over 2-fold. These results suggest that, during chronic ethanol ingestion, decreased activities of Δ⁹-desaturases are due mainly to a decreased content of the terminal component of the desaturase system.

【 授权许可】

Unknown