Effects of bovine parathyroid hormone and 1,25‐dihydroxyvitamin D3 on the production of prostaglandins by cells derived from human bone

FEBS Letters

Russell, R.Graham G.¹  Gallagher, James A.¹  Gowen, Maxine¹  MacDonald, Brian R.¹  Beresford, Jon N.¹  Ahnfelt-Ronne, Ian² 

[1] Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, England;Department of Pharmacology, Leo Pharmaceutical Products, DK 2750, Ballerup, Denmark

关键词: Human bone cell;    Prostaglandin;    PTH;    1;    25-Dihydroxyvitamin D3;   

DOI  :  10.1016/0014-5793(84)80287-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Local production of prostaglandins by osteoblasts may be important in controlling the bone resorbing activity of some hormones which have receptors on osteoblasts. We have demonstrated that osteoblast-like cells derived from human bone can incorporate [¹⁴C]arachidonic acid into phospholipids and synthesise immunoreactive PGE. Parathyroid hormone increases both the release of incorporated arachidonic acid and the synthesis of PGE. This is the first demonstration of modulation of bone cell prostaglandin synthesis by a bone resorbing hormone.

【 授权许可】

Unknown