Different adhesion inhibiting activities of antisera against plasma membranes of liver and Morris hepatoma 7777

FEBS Letters

Dethlefs, Ulrike¹  Reutter, Werner¹  Neumeier, Reinhard¹ 

[1] Institut für Molekularbiologie und Biochemie der Freien Universität Berlin, Arnimallee 22, D-1000 Berlin 33 (Dahlem), Germany

关键词: Cell-substratum adhesion;    Collagen;    Plastic;    Hepatocyte;    Hepatocarcinoma;    Plasma membrane;   

DOI  :  10.1016/0014-5793(84)80254-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cell-substratum adhesion of rat hepatocytes was inhibited by antisera raised against plasma membranes of liver (anti-liver antiserum) and Morris hepatoma 7777 (anti-hepatoma antiserum). Similar concentrations of both antisera inhibited adhesion on collagen. Anti-liver antiserum also inhibited the adhesion of hepatocytes on plastic, whereas anti-hepatoma antiserum was only able to inhibit the adhesion on collagen completely. These results suggest the existence of at least two different adhesion-involved molecules. Cells adhere to plastic by means of both molecules, whereas adhesion on collagen is mediated by only one of them. The results further suggest that hepatoma cells lost the molecule involved in adhesion on plastic.

【 授权许可】

Unknown