‘Molecular sandwiches’ as a basis for structural and functional similarities of interferons, MSH, ACTH, LHRH, myelin basic protein, and albumins

FEBS Letters

Root-Bernstein, Robert Scott¹ 

[1] The Salk Institute for Biological Studies, PO Box 85800, San Diego, CA 92138-9216, USA

关键词: MSH;    ACTH;    LHRH;    Myelin basic protein;    Interferon;    Albumin;   

DOI  :  10.1016/0014-5793(84)80247-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Sequential similarities between the tryptohan peptide of myelin basic protein (residues 111–121), luteinizing hormone releasing hormone, melanotropin, adrenocorticotropin (residues 1–13), human leukocyte interferon (residues 28–40), and various segments of human and bovine serum albumin and hen ovalbumin are presented. It is suggested that these structural similarities may explain observations concerning common functional characteristics such as serotonin modulation, immunological activity with the adjuvant muramyl dipeptide, immunological cross-reactivity, and the possible MSH-ACTH-like activity of a pepsin-derived peptide of interferon.

【 授权许可】

Unknown