Paramagnetic metalloporphyrins as potential contrast agents in NMR imaging

FEBS Letters

Cohen, Jack S.¹  Myers, Charles E.¹  Chen, Chi-wan¹  Sohn, Miriam¹ 

[1] Clinical Pharmacology Branch, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA

关键词: Metalloporphyrin;    NMR imaging;    Paramagnetic reagent;    NMR contrast agent;   

DOI  :  10.1016/0014-5793(84)80208-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Several water-soluble paramagnetic metalloporphyrins were found to increase significantly the relaxation rate (1/T ₁) of water. Such compounds are known to be selectively retained by tumors in animals, and consequently we identify them as potential contrast agents for tumors in NMR imaging.

【 授权许可】

Unknown