The organ uptake of intravenously administered colloidal particles can be altered using a non‐ionic surfactant (Poloxamer 338)

FEBS Letters

Davis, S.S.¹  Illum, L.² 

[1]Department of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, England

[2]Royal Danish School of Pharmacy, 2 Universitetsparken, 2100 Copenhagen O, Denmark

关键词: Colloidal particle;    Reticuloendothelial system;    Poloxamer;    Drug targeting;    Non-ionic surfactant;    Phagocytosis;   

DOI  :  10.1016/0014-5793(84)80836-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Small polystyrene particles coated with a high M _r non-ionic surfactant (Poloxamer 338) are diverted from the reticuloendothelial system of the liver and spleen to other tissue sites. These results are discussed in terms of the adsorption of the Poloxamer to the particle surface and the implications for drug targeting.

【 授权许可】

Unknown