Interaction of synthetic signal sequence fragments with model membranes

FEBS Letters

Nagaraj, R.¹ 

[1]Centre for Cellular and Molecular Biology, R.R.L. Campus, Hyderabad 500 007, India

关键词: Signal sequence;    Synthetic peptide;    Fluorescence;    Model membrane;    Boc;    t-butyloxycarbonyl;    Bzl;    benzyl;    dans;    5-dimethylaminoaphthalene-1-sulfonyl;    DMPC;    dimyristoylphosphatidylcholine;    EPC;    egg phosphatidylcholine;    Hepes;    N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid;    OBzl;    benzyl ester;    OMe;    methyl ester;   

DOI  :  10.1016/0014-5793(84)80018-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Peptide fragments corresponding to the signal sequence of chicken lysozyme, labelled with the fluorescent 5-dimethylaminoaphthalene-1-sulfonyl(dansyl) group have been synthesized. The emission characteristics and fluorescence polarization of the dansyl group have been used to study the interaction of signal sequence fragments with liposomes. The peptide fragments bind to liposomes and are associated with the hydrophobic core of the bilayer.

【 授权许可】

Unknown