Induction of 2′,5′ oligo(A) synthetase in tumor‐bearing mice with encephalomyocarditis (EMC) virus of poly(I)poly(C)

FEBS Letters

Galaktidou, G.¹  Koliais, S.I.¹  Kortsaris, A.¹ 

[1] Theagenion Cancer Institute, Serron 2, Thessaloniki, Greece

关键词: C3H mice;    Encephalomyocarditis virus;    Poly(I)poly(C);    2′;    5′ Oligo(A) synthetase;    Induction of 2′;    5′ oligo(A) synthetase;    Spontaneous tumor;   

DOI  :  10.1016/0014-5793(83)80041-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Infection of 13 month-old C₃H mice with EMC virus or inoculation with the interferon inducer poly(I)poly(C) results in elevated levels of the enzyme 2′,5′ oligo(A) synthetase only in animals with spontaneous tumors (breast cancer or hepatomas). High enzymatic activities are detected in homogenates from liver, spleen, plasma and neoplastic cells of the animals with breast carcinomas and only in the neoplastic liver cells of the animals with hepatomas.

【 授权许可】

Unknown