Oxidation of myoglobin in isolated adult rat cardiac myocytes by 15‐hydroperoxy‐5,8,11,13‐eicosatetraenoic acid

FEBS Letters

Kennedy, Frances G.¹  Jones, Dean P.¹  Walters, Frederick P.¹ 

[1] Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA

关键词: Myoglobin;    Arachidonate;    Heart;    Prostaglandin;    Lipid peroxide;    Oxidation;   

DOI  :  10.1016/0014-5793(83)80838-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The oxidation of intracellular myoglobin by 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid was studied in suspensions of isolated adult rat heart cells. Myoglobin was converted to a species identified as ferrylMb by its reaction with Na₂S to form ferrous sulfmyoglobin. This process was time-dependent and concentration-dependent in a manner consistent with direct accessibility of the exogenous peroxide to the cytosolic protein. The results indicate that myoglobin oxidation may be an early sign of oxidative injury and may limit myocardial function by elimination of this short-term O₂ reserve.

【 授权许可】

Unknown