Effect of fatty acid anilides on the generation of arachidonic acid by human polymorphonuclear leukocytes

FEBS Letters

Mato, Jose M.²  Municio, Angel M.¹  Garcia Gil, Mercedes²  van Lookeren Campagne, Michiel W.²  Alemany, Susana² 

[1] Dept. of Biochemistry, Facultad de Ciencias, Universidad Complutense de Madrid, Madrid 3, Spain;Metabolismo, Nutricion y Hormonas, Fundacion Jimenez Diaz, Reyes Catolicos 2, Madrid 3, Spain

关键词: Oleoylanilide Linoleylanilide Triacylglycerol Phospholipid Arachidonic acid Human neutrophil;   

DOI  :  10.1016/0014-5793(83)81068-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The addition of oleoylanilide or linoleylanilide to human polymorphonuclear leukocytes induces a time-and dose-dependent generation of arachidonic acid. Half-maximal effect is caused by a dose of 0.2 mg linoleylanilide/ml. Fatty acid anilides also produce a time- and dose-dependent inhibition of the synthesis of triacylglycerol. Half-maximal effect is caused by 1 μg linoleylanilide/ml. These results indicate that fatty acid anilides, which have been found in the illegal cooking oil which intoxicated thousands of Spaniards, alter lipid metabolism in human polymorphonuclear leukocytes.

【 授权许可】

Unknown