A low‐M r factor isolated from Escherichia coli inhibits eukaryotic in vitro protein synthesis

FEBS Letters

Skelly, Susan M.¹  Clark, Virginia L.¹ 

[1]Department of Microbiology, Box 672, University of Rochester Medical Center, Rochester, NY 14642, USA

关键词: Translation;    Initiation;    Escherichia coli;    Protein synthesis inhibitor;    Protein synthesis inhibition;    Cell-free system;   

DOI  :  10.1016/0014-5793(83)81040-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of a low-M _r factor, partially purified from E. coli B, was investigated in E. coli, reticulocyte, and wheat germ lysate in vitro protein synthesis systems. Equal concentrations of factor were needed to inhibit protein synthesis in the eukaryotic system as compared to the prokaryotic system. Experiments suggested that the factor inhibits the initiation step in the eukaryotic systems.

【 授权许可】

Unknown