A topological model for chromatin transcription and a role for nucleosome linkers

FEBS Letters

Krasheninnikov, Igor A.¹  Grigoryev, Sergei A.¹ 

[1]Department of Molecular Biology, Biological Faculty, Moscow State University, Moscow 117234, USSR

关键词: Chromatin;    Nucleosome;    Transcription;    RNA polymerase;    DNA topology;    Supranucleosomal organization;   

DOI  :  10.1016/0014-5793(83)81037-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

There is a good deal of evidence that transcribing RNA polymerase may translocate across nucleosomes without their displacement and (or) rearrangement. A topological model for RNA chain elongation on a nucleosome is considered here. A new mechanism of RNA polymerase translocation is suggested in order to avoid the steric hindrances inherent in the model. It is shown that a transcribed nucleoprotein fiber should be interrupted by protein-free DNA stretches (nucleosome linkers) to allow release of nascent RNA. Possible verificiations and consequences of the model are discussed.

【 授权许可】

Unknown