Regulation of cockroach flight muscle phosphofructokinase by fructose 2,6‐bisphosphate

FEBS Letters

Storey, Kenneth B.¹ 

[1] Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada

关键词: Phosphofructokinase;    Fructose 2;    6-bisphosphate;    Insect flight muscle;    Activation of glycolysis;   

DOI  :  10.1016/0014-5793(83)81022-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Fructose 2,6-bisphosphate is a potent activator of cockroach flight muscle 6-phosphofructo-1-kinase; at 5 μM, fructose 2,6-P₂ lowers S _0.5 for fructose 6-P 36-fold from 16 ± 0.90 to 0.44 ± 0.14 mM. Muscle concentration of fructose 2,6-P₂ is elevated at the initiation of flight suggesting that the compound plays a key role in the activation of muscle phosphofructokinase, and therefore in the activation of glycolytic flux, during the initiation of flight.

【 授权许可】

Unknown