Co‐operation between metastatic tumor cells and macrophages in the degradation of basement membrane (type IV) collagen

FEBS Letters

Henry, Nicole¹  van Lamsweerde, Anne-Louise¹  Eeckhout, Yves¹  Vaes, Gilbert¹ 

[1] Laboratoire de Chimie Physiologique, Université de Louvain and International Institute of Cellular and Molecular Pathology, Avenue Hippocrate, 75, B-1200 Bruxelles, Belgium

关键词: Basement membrane degradation;    Type IV collagenase;    Cancer cell;    Macrophage;    Cell interaction;    Metastasis;   

DOI  :  10.1016/0014-5793(83)81017-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The co-culture of mouse peritoneal macrophages and Lewis lung carcinoma cells induces the relase of a metal-dependent type IV collagen-degrading proteinase which is not produced in detactable amounts by either cell type cultivated alone. Conditioned media of the co-cultures degrade both pepsin-extracted type IV collagen from human placenta and mouse type IV procollagen. Thus macrophages can interact with tumor cells to degrade basement membrane type IV collagen: this might be of importance to allow cancer invasion and metastasis.

【 授权许可】

Unknown