Adenylate cyclase inhibition by hormones

FEBS Letters

Bockaert, Joel¹  Sebben-Perez, Michele¹ 

[1] Centre CNRS, INSERM de Pharmacologie, Endocrinologie, Rue de la Cardonille, BP 5055, 34033 Montpellier Cédex, France

关键词: Adenylate cyclase inhibition;    Magnesium;    Guanosine-triphosphate;   

DOI  :  10.1016/0014-5793(83)80741-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In washed anterior pituitary membranes, there is enough GTP to occupy N _s and therefore to obtain activation of adenylate cyclase by vasointestinal peptide. GTP concentrations needed to obtain adenylate cyclase inhibition by dopamine (above 5 × 10⁻ M) stimulate the adenylate cyclase. The dopamine efect is a blockade of this stimulation. We propose that at least in this system, N _i does not inhibit but stimulates the adenylate cyclase and that inhibitory hormones block this stimulation. We also demonstrate in several adenylate cyclase systems that hormones produced adenylate cyclase inhibition by lowering their Mg affinity A general model for adenylate cyclase activation and inhibition is proposed.

【 授权许可】

Unknown