Separation of Fe+3 from transferrin in endocytosis

FEBS Letters

Klausner, R.D.¹  Rao, K.¹  Kempf, C.¹  van Renswoude, J.¹ 

[1] Laboratory of Biochemistry and Metabolism, NIADDK, National Institutes of Health, Bethesda, MD 20205, USA

关键词: Transferrin;    Endocytosis;    K562 cell;    Acidic compartment;    Monensin;    NH4Cl;   

DOI  :  10.1016/0014-5793(83)80969-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

NH₄Cl and monensin, two agents which neutralize intracellular acidic compartments, block the segregation of iron from transferrin after endocytosis, while neither of these reagents affects internalization of diferric transferrin into the cell. In conclusion the molecular separation of iron from transferrin inside the cell requires a non-lysosomal acidic compartment

【 授权许可】

Unknown