Acetyl glyceryl ether phosphorylcholine (platelet‐activating factor) mediates heightened metabolic activity in macrophages

FEBS Letters

Hartung, Hans-Peter¹ 

[1] Department of Neurology, University of Düsseldorf, Moorenstr. 5, 4000 Düsseldorf, FRG

关键词: Platelet-activating factor;    Macrophage;    Prostanoid;    O− 2;    Spreading;    Calmodulin antagonis W-7;   

DOI  :  10.1016/0014-5793(83)80968-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The phospholipid mediator AGEPC (acetyl glyceryl ether phosphorylcholine) was examined for its effects on guinea pig peritoneal macrophages. At a concentration of 10⁻⁹ -10⁻⁶ M, AGEPC evoked release of prostaglandin E (PGE) and thromboxane B₂ (TXB₂) from albumin-elicited macrophages. It also triggerd generation of O⁻ ₂ by Corynebacterium parvum-induced cells. Moreover, it caused augmented spreading of macrophages. The calmodulin antagonis W-7 attenuated AGEPC-mediated O⁻ ₂ production and cell spreading whereas prostanoid synthesis was enhanced. These novel actions of AGEPC on the major cellular component of the inflammatory process attest to its role as a potent mediator of immunoinflammatory responses.

【 授权许可】

Unknown