The effect of N‐methylprotoporphyrin and succinyl‐acetone on the regulation of heme biosynthesis in chicken hepatocytes in culture

FEBS Letters

De Matteis, Francesco¹  Marks, Gerald S.¹ 

[1] Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario K7L 3N6, Canada

关键词: Porphyria;    Heme;    N-Methylprotoporphyrin;    5-Aminolevulinic acid synthase 3;    5-Diethoxycarbonyl-1;    4-dihydrocollidine;    (Liver);   

DOI  :  10.1016/0014-5793(83)80430-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The essential features of hepatic protoporphyria, namely inhibition of ferrochelatase, accumulation of protoporphyrin and stimulation of 5-aminolevulinic acid synthase (ALA-S) were all obtained by treating chicken hepatocytes in culture with small doses of N-methylprotoporphyrin. Both N-methylprotoporphyrin and succinyl-acetone, another inhibitor of heme biosynthesis, stimulated ALA-S when given on their own and also enhanced the stimulation of ALA-S caused by phenobarbital.

【 授权许可】

Unknown