Synthetic peptides mimic subtype specificity of foot‐and‐mouth disease virus

FEBS Letters

Lerner, R.A.¹  Brown, F.²  Houghten, R.A.¹  Carroll, A.R.²  Nicholson, B.H.³  Clarke, B.E.²  Rowlands, D.J.² 

[1] Research Institute of Scripps Clinic, La Jolla, CA 92037, USA;Biochemistry Department, Animal Virus Research Institute, Pirbright, Woking, Surrey GU24 0NF, England;Department of Physiology and Biochemistry, University of Reading, England

关键词: Picornavirus;    Foot-and-mouth disease virus;    Antigenic variation;    Synthetic peptide;    Structural model;   

DOI  :  10.1016/0014-5793(83)80558-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The major immunogen of foot-and-mouth disease virus (FMDV) is located between amino acids 141–160 of the capsid protein VP1. Synthetic peptides corresponding to the major immunogenic region give good neutralising antibody responses and protection in guinea pigs. To define more precisely the immunogenic site of the virus, we have examined serological differences between subtypes of the A serotype using synthetic peptides covering the 141–160 region. We show that these synthetic peptides carry determinants which mimic the subtype specificity of the virus. The correlation between these results and predictive structural models, based on the amino acid sequence, is discussed.

【 授权许可】

Unknown