A helix dipole model for alamethicin and related transmembrane channels

FEBS Letters

Mathew, M.K.¹  Balaram, P.¹ 

[1] Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India

关键词: Membrane channel;    Alamethicin;    Helix dipole;    Amphipathic helix;    Membrane transport;    Peptide aggregation;   

DOI  :  10.1016/0014-5793(83)81105-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A molecular model is proposed for the transmembrane channels formed by alamethicin and related polypeptides. The channels consist of an aggregate of rod-like helical polypeptides with a central aqueous core of ordered water. The helix dipole moment is considered to be the major factor modulating channel size, selectivity and field-dependent transitions.

【 授权许可】

Unknown