Will the seven‐helix bundle be a common structure for integral membrane proteins?

FEBS Letters

Mohana Rao, J.K.²  Argos, Patrick²  Hargrave, Paul A.¹ 

[1] Department of Medical Biochemistry (School of Medicine) and Department of Chemistry and Biochemistry (College of Science), Southern Illinois University, Carbondale, IL 62901, USA;Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA

关键词: Membrane protein;    Thylakoid membrane;    Rhodopsin;    Protein structure;    Bacteriorhodopsin;    Helix;   

DOI  :  10.1016/0014-5793(83)80270-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A prediction algorithm, designed to detect lipid-embedded helical regions in membrane proteins, was applied to the amino acid sequence of a chloroplast thylakoid membrane protein important in photosynthesis. It is suggested that the thylakoid membrane protein consists of 7 transmembrane helices connected by exposed turn segments, similar to current models for bacteriorhodopsin and bovine rhodopsin. This basic structural feature, the 7-helical bundle, may prove to be shared by many integral membrane proteins.

【 授权许可】

Unknown