Activation of the respiratory burst of guinea pig neutrophils by dicyclohexylcarbodiimide

FEBS Letters

Aviram, Irit¹  Aviram, Adina¹ 

[1] The Department of Biochemistry, Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv, 69978, Israel

关键词: Dicyclohexylcarbodiimide;    Superoxide;    Respiratory burst;    Neutrophil;   

DOI  :  10.1016/0014-5793(82)80603-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

DCCD activates the respiratory burst in guinea pig peritoneal neutrophils. The onset of the superoxide producing activity is preceeded by a lag, inversely proportional to the dose of the stimulant and to the temperature. Initial rates of superoxide formation exhibit different dependencies on the concentrations of DCCD and on temperature. Activation of NAD(P)H oxidase is inhibited by preincubation of neutrophils with 2-deoxyglucose and does not require the presence of extra cellular Ca²⁺.

【 授权许可】

Unknown