Factor XIII‐mediated cross‐linking of NH2‐terminal peptide of α2‐plasmin inhibitor to fibrin

FEBS Letters

Aoki, Nobuo¹  Ichinose, Akitada¹  Tamaki, Taro¹ 

[1] Institute of Hematology and Department of Medicine, Jichi Medical School, Tochigi-Ken 329-04, Japan

关键词: α2-Plasmin inhibitor;    Fibrin;    Factor XIII;    Plasma transglutaminase;    Cross-linking;    Glutamine substrate;    α2PI;    α2-plasmin inhibitor;    XIIIa;    activated coagulation factor XIII;    N-peptide;    NH2-terminal peptide of α2PI;   

DOI  :  10.1016/0014-5793(83)80645-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The NH₂-terminal 12-residue peptide of α₂-plasmin inhibitor, Asn—Gln—Glu—Gln—Val—Ser—Pro—Leu—Thr—Gly—Leu—Lys—NH₂ ·AcOH, was found to be a good substrate for plasma transglutaminase (activated blood coagulation factor XIII) and rapidly incorporated into fibrin by the enzyme. A high concentration of the peptide inhibited the enzyme-mediated cross-linking of α₂-plasmin inhibitor to fibrin probably by competing with the inhibitor for the same site of fibrin α-chain.

【 授权许可】

Unknown