Hemoglobin Kariya [α40 (C5) Lys → Glu]: a new hemoglobin variant with an increased oxygen affinity

FEBS Letters

Yamada, H.⁵  Shibata, S.⁴  Ueda, S.⁴  Fukui, H.¹  Tsuneshige, A.²  Harano, T.⁴  Imai, K.²  Seki, M.³  Harano, K.⁴ 

[1] Health Service Department, Nippondenso Co., Ltd., Kariya 448, Japan;Department of Physicochemical Physiology, Medical School, Osaka University, Nakanoshima, Osaka 530, Japan;Division of Clinical Laboratory, Hekinan-shi Medical Association, Hekinan 477, Japan;Department of Biochemistry and Medicine, Kawasaki Medical School, Kurashiki 701-01, Japan;Department of Medicine, Medical School, Nagoya University, Tsurumai, Nagoya 466, Japan

关键词: Hemoglobin Kariya [α40 (C5) Lys → Glu] α1β2 Contact High oxygen affinity;   

DOI  :  10.1016/0014-5793(83)80636-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new abnormal hemoglobin, Hb Kariya [α40 (C5) Lys → Glu], with an amino acid substitution at the α₁β₂ contact was discovered in a young Japanese man. This variant migrated to the anode faster than Hb A, being nearly the same as Hb I in electrophoretic mobility. It amounted to about 6% of the total hemoglobin of the hemolysate. This hemoglobin showed an increased oxygen affinity, decreased heme—heme interaction and a lowered 2,3-DPG effect.

【 授权许可】

Unknown