The disulphide bonds of an Asian influenza virus neuraminidase

FEBS Letters

Colman, Peter M.¹  Ward, Colin W.¹  Laver, W.Graeme² 

[1] CSIRO, Division of Protein Chemistry, Parkville, VIC 3052, Australia;Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia

关键词: Influenza virus neuraminidase Disulphide bond;   

DOI  :  10.1016/0014-5793(83)80113-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The arrangement of the disulphide bonds in the pronase-released neuraminidase heads of the Asian influenza virus A/Tokyo/3/67 have been examined by cyanogen bromide fragmentation, enzymic digestion and diagonal peptide mapping. There are 9 intrachain disulphide bridges and one interchain bridge which links pairs of monomers at the distal end of the stalk region of the neuraminidase tetramer. The disulphide bond arrangements of the remaining 3 half-cystine residues in the membrane-embedded stalk region of the neuraminidase were not examined.

【 授权许可】

Unknown