FEBS Letters | |
Ecdysone and 20 hydroxyecdysone: new hormones for the human parasite Schistosoma mansoni | |
Nirde, Ph.1  De Reggi, M.L.2  Torpier, G.1  Capron, A.1  | |
[1] Centre d'Immunologie et de Biologie Parasitaire, INSERM (U. 167), CNRS (ERA 422), Institut Pasteur, 15 rue Camille Guérin, B.P. 245, 59019 Lille Cédex, France;Centre d'Immunologie INSERM-CNRS, Case 906, 13288 Marseille Cédex 9, France | |
关键词: Schistosoma mansoni; Fasciola hepatica; Ecdysone/analysis; Ecdysterone/analysis; Radio immunoassay — chromatography; high pressure liquid; | |
DOI : 10.1016/0014-5793(83)80074-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The insect moulting hormones, ecdysone and 20 hydroxyecdysone, were detected by the combined use of radioimmunoassay and high performance liquid chromatography in the human parasite Schistosoma mansoni. On day 11 after infection only the ecdysone form is present, but, on day 40 after infection the ratio between ecdysone and 20 hydroxyecdysone changes with anatomic localization of the adult worms in mammalian host. In the eggs, the ratio of these two hormones is identical to the ratio found in sexually mature worms located in mesenteric veins. These data demonstrate for the first time that S. mansoni synthesizes the steroid hormones ecdysone and 20 OH ecdysone which are potent molecules in stimulating growth and vitello-genesis of this gonochoric trematode.
【 授权许可】
Unknown
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