Rifamycin B. oxidase from Monocillium spp., a new type of diphenol oxidase

FEBS Letters

Han, Moon H.¹  Tae-Ick, Mheen¹  Baik-Lin, Seong¹  Son, Hyeung-Jin¹ 

[1] Biotechnology Research Department, The Korea Advanced Institute of Science and Technology, PO Box 131, Dong Dae Mun, Seoul, Korea

关键词: Polyphenol oxidase;    Rifamycin B oxidase;    Biotransformation Antibiotic;    Rifamycin;    Enzyme;   

DOI  :  10.1016/0014-5793(83)80337-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It was found that enzyme from a microbial strain, Monocillium spp. ATCC 20621, catalyzed the oxidative reaction of rifamycin B to form rifamycin O. The identification of the reaction products suggested that the reaction proceeded by the oxidative cyclization of rifamycin B to give rifamycin O, which spontaneously hydrolyzed to rifamycin S in neutral aqueous milieu. The characteristic of the enzyme was different as compared with that of other polyphenol oxidases such as laccase. It is proposed that this new type of enzyme be classified into a subgroup EC 1.10.3.6 with a trival name rifamycin B oxidase.

【 授权许可】

Unknown