Different regulation of the concentration of estrogen receptors in the rat liver and uterus following ovariectomy

FEBS Letters

Eriksson, Håkan A.¹ 

[1] Department of Chemistry, Karolinska Institutet, Box 60 400, S-104 01 Stockholm 60, Sweden

关键词: Estrogenreceptor;    Ovariectomy;    Rat liver;    Rat uterus;    Receptor synthesis;   

DOI  :  10.1016/0014-5793(82)81078-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Data concerning the short- and longterm effects of ovariectomy on the levels of estrogen binding sites in the rat uterus and liver are presented. The information increases the understanding of the regulation of estrogen receptor synthesis. The circulating estrogen level is suggested to affect receptor synthesis in the uterus and liver differently. Shortly after gonadectomy (2–20h), an elevation in the concentration of cytoplasmic binding sites in the uterus of 35% was observed, whereas no effect was seen in the liver cell. A longer period of time after ovariectomy (2–3 months) caused a reduction in the number of uterine receptor sites by 74%, whereas in the liver an increase of 84% was detected.

【 授权许可】

Unknown