The possible roles of the myosin heads

FEBS Letters

Garrigos, Manuel¹  Morel, Jean E.¹ 

[1] Département de Biologie, Service de Biophysique, CEN-Saclay, 91191 Gif-sur-Yvette Cédex France

关键词: Myosin filament;    Head-to-head interaction;    ADP;    adenosine diphosphate;    ATP;    adenosine triphosphate;    Pi;    inorganic phosphate;    S1;    myosin subfragment 1 (head);    S1 (A1);    S1 containing only the A1 (or LC1) light chain;    S1 (A2);    S1 containing only the A2 (or LC3) light chain;    DTT;    dithiothreitol;    apparent specific volume;   

DOI  :  10.1016/0014-5793(82)81061-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is suggested that, in the conditions which exist in vivo, one head of a myosin molecule interacts with another head of the opposite molecule, inside the backbone of the thick filament. The other head lies outside and can interact with actin. This model is based on the fact that a dimer of the myosin heads exists and that there is a close correlation between the properties of the dimer and those of the thick filament diameter. In natural filaments, there are myosin molecules in excess and it is suggested that these molecules have their two heads outside the backbone.

【 授权许可】

Unknown