Inhibition of DNA replication in vitro by pefloxacin

FEBS Letters

Kohiyama, Masamichi¹  Hughes, Patrick¹  Badet, Bernard²  Forterre, Patrick¹ 

[1] CNRS-Institutde Recherche en Biologie Moléculaire, Université Paris VII, tour 43, 2 place Jussieu 75221 Paris cédex 05, France;CNRS-CERCOA (laboratoire associé à l'ENSCP) 2 à 8, rue Henry Dunant 94320 Thiais France

关键词: Pefloxacin;    Nalidixic acid;    DNA replication;    DNA Polymerase I;    Toluenized cell;    oriC plasmid;   

DOI  :  10.1016/0014-5793(82)80199-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pefloxacin (a novel quinolone antibiotic) is demonstrated to be a drug inhibiting DNA replication 10-times more efficiently than oxolinic acid measured either in toluene-treated E. coli or in an in vitro replication system for oriC plasmids [6]. DNA repair synthesis is not inhibited by the drug.

【 授权许可】

Unknown