ASSOCIATION BETWEEN PAPP-A AND PLACENTAL THICKNESS

Iranian journal of reproductive medicine

ABEDZADEH KALAHROODI MASOOMEH¹  MESDAGHI NIA ELAHEH¹  BEHRASHI MITRA¹  SAEIDI AREZOO¹  SEHAT MOJTABA¹ 

关键词: PREGNANCY-ASSOCIATED PLASMA PROTEIN-A (PAPP-A);    PREGNANCY;    PLACENTA;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Measuring of maternal serum pregnancy-associated plasma protein-A (PAPP-A) in first trimester can be a way for early detection of adverse prenatal outcome due to faulty placenta.Objective: The aim was to Determination of association between placental thickness in second trimester with low level of PAPP-A in first trimester.Materials and Methods: In this cohort study, serum PAPP-A of 187 pregnant women was measured in the first trimester of pregnancy. Patients who had PAPP-A£0.8 MOM were in exposed and others who had PAPP-A >0.8 defined as unexposed group. The criteria of placental thickness in ultrasound study was thickness of 4 cm or more than 50% of placental length.Results: Of 187 patients, 87 patients had PAPP-A >0.8 and 93 patients had PAPP-A£0.8. Women with low levels of PAPP-A in the first trimester, had an increased incidence placental thickness of 34.4%, whereas another group had about 15% (p=0.002). Also, PAPP-A levels had acceptable sensitivity and specificity for placental thickness detection (71.1% and 54.8%, respectively.Conclusion: Our study showed that serum level of PAPP-A generally was low (£0.8) in women with a thick placenta (>4 cm or >50% of placental length). The first trimester of pregnancy measurement of PAPP-A will be more predictable for healthy placenta.

【 授权许可】

Unknown