Iranian journal of reproductive medicine | |
SIGNIFICANT CORRELATION OF ANGIOTENSIN CONVERTING ENZYME AND GLYCOPROTEIN IIIA GENES POLYMORPHISMS WITH UNEXPLAINED RECURRENT PREGNANCY LOSS IN NORTH OF IRAN | |
FARAZMANDFAR TOURAJ1  HASHEM SOTEH SEYED MOHAMMAD BAGHER1  FAZELNIA SHOKOUFEH1  | |
关键词: ANGIOTENSIN CONVERTING ENZYME; PLATELET GLYCOPROTEIN IIIA; RECURRENT ABORTION; | |
DOI : | |
学科分类:药学、药理学、毒理学(综合) | |
来源: Shahid Sadoughi University of Medical Sciences, Yazd | |
【 摘 要 】
Background: Spontaneous abortion is considered as the most complex problem during pregnancy. Thrombophilia is resumed as a cause of recurrent pregnancy loss (RPL). Glycoprotein IIIa (GPIIIa) gene is involved in thrombosis and abortion. Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II and is involved in thrombosis. The most common polymorphism in this gene is the insertion/deletion (I/D).Objective: In this study, we analyzed the association between ACE I/D and GPIIIa c.98C>T polymorphisms in women with unexplained RPL from the north of Iran.Materials and Methods: Sample population consisted of 100 women with unexplained RPL and 100 controls. The ACE I/D and GPIIIa c.98C>T polymorphisms were genotyped by TETRA-ARMS PCR. The association between genotypes frequency and RPL were analyzed using c2 and exact fisher tests. Associated risk with double genotype combinations was also investigated by binary logistic regression.Results: There was significant association between ACE DD genotype and RPL (OR=2.04; 95% CI=0.94-4.44; p=0.036). ACE D Allele was also significantly associated with the RPL (OR=1.59; 95% CI=1.05-2.41; p=0.013). No significant association was observed between GPIIIa c.98C>T polymorphism and RPL.Conclusion: ACE I/D polymorphism may probably be a prognostic factor in female family members of women with the history of recurrent abortion.
【 授权许可】
Unknown
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