SIGNIFICANT CORRELATION OF ANGIOTENSIN CONVERTING ENZYME AND GLYCOPROTEIN IIIA GENES POLYMORPHISMS WITH UNEXPLAINED RECURRENT PREGNANCY LOSS IN NORTH OF IRAN

Iranian journal of reproductive medicine

FARAZMANDFAR TOURAJ¹  HASHEM SOTEH SEYED MOHAMMAD BAGHER¹  FAZELNIA SHOKOUFEH¹ 

关键词: ANGIOTENSIN CONVERTING ENZYME;    PLATELET GLYCOPROTEIN IIIA;    RECURRENT ABORTION;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Spontaneous abortion is considered as the most complex problem during pregnancy. Thrombophilia is resumed as a cause of recurrent pregnancy loss (RPL). Glycoprotein IIIa (GPIIIa) gene is involved in thrombosis and abortion. Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II and is involved in thrombosis. The most common polymorphism in this gene is the insertion/deletion (I/D).Objective: In this study, we analyzed the association between ACE I/D and GPIIIa c.98C>T polymorphisms in women with unexplained RPL from the north of Iran.Materials and Methods: Sample population consisted of 100 women with unexplained RPL and 100 controls. The ACE I/D and GPIIIa c.98C>T polymorphisms were genotyped by TETRA-ARMS PCR. The association between genotypes frequency and RPL were analyzed using c2 and exact fisher tests. Associated risk with double genotype combinations was also investigated by binary logistic regression.Results: There was significant association between ACE DD genotype and RPL (OR=2.04; 95% CI=0.94-4.44; p=0.036). ACE D Allele was also significantly associated with the RPL (OR=1.59; 95% CI=1.05-2.41; p=0.013). No significant association was observed between GPIIIa c.98C>T polymorphism and RPL.Conclusion: ACE I/D polymorphism may probably be a prognostic factor in female family members of women with the history of recurrent abortion.

【 授权许可】

Unknown