THE RELATIONSHIP BETWEEN SOME ENDOMETRIAL SECRETION CYTOKINES AND IN VITRO FERTILIZATION

Iranian journal of reproductive medicine

EZZATI MOHAMMAD¹  MOADDAB AMIRHOSSEIN¹  ABDOLLAH SHAMSHIRSAZ ALIREZA¹  RAHIMINEJAD MOHAMMAD EHSAN¹  RABIEE SOGHRA¹  EBRAHIMI MEHRNOOSH¹  ZAMANI ALIREZA¹ 

关键词: CYTOKINE;    IN VITRO FERTILIZATION;    OUTCOME;    ENDOMETRIUM;    IMPLANTATION;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity.Objective: The aim of the present study was to assess the relationship between the success rate of IVF procedures and some endometrial secretion cytokines, including interleukin-1b (IL-1 b), tumor necrosis factor (TNF-a), interferon gamma-induced protein 10 (IP-10), and monocyte chemoattractant protein (MCP).Materials and Methods: In a prospective cohort study, 50 women selected for IVF met the study inclusion criteria. All the patients underwent endometrial secretion aspiration prior to embryo transfer. The level of IL-1 b, TNF-a, IP-10 and MCP were analyzed by enzyme-linked immunosorbent assay method using special standard kits. To detect successful implantation and pregnancy patients underwent serum human chorionic gonadotropin measurements and ultrasound evaluation.Results: Five samples were excluded. Nine women (20%) had successful clinical pregnancies, which resulted in live birth. Other 36 women (80%) were classified as failed pregnancy. Comparison of cytokine levels showed lower concentrations of TNF-a, IP-10, and MCP in the group with successful clinical pregnancy compared to the group with failed pregnancy (p=0.007, 0.005 and 0.001, respectively). However, no significant difference was revealed in IL-1 b levels between two groups (p=0.614).Conclusion: The current study suggested that lower concentrations of TNF-a, IP-10, and MCP in endometrial secretions might be associated with improved endometrial receptivity and IVF outcome. Regarding IL-1 b, no statistically significant differences were seen between the groups with and without successful pregnancy.

【 授权许可】

Unknown