OXIDATIVE STRESS AND ANTI-OXIDANT DEFENSE SYSTEM IN IRANIAN WOMEN WITH POLYCYSTIC OVARY SYNDROME (SHORT COMMUNICATION)

Iranian journal of reproductive medicine

AMINI LEILA¹  KAMALZADEH SARA¹  MOTI MAHTAB¹  JAFARISANI MOSLEM¹  MASOOMIKARIMI MASOOMEH¹  MIRHOSEINI ARDAKANI SOHEILA SADAT¹ 

关键词: POLYCYSTIC OVARY SYNDROME;    INFERTILITY;    CRP;    ANTIOXIDANT;    AOPP;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes. Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran. Materials and Methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples. Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women. Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.

【 授权许可】

Unknown