LACK OF ASSOCIATION OF DRD3 AND CNR1 POLYMORPHISMS WITH PREMENSTRUAL DYSPHORIC DISORDERS

Iranian journal of reproductive medicine

KARABABA IBRAHIM FATIH¹  YILDIZ MESUT¹  YILMAZ SENAY GORUCU¹  VURAL MEHMET¹  AY OZLEM IZCI¹  ERDAL MEHMET EMIN¹  SELEK SALIH¹ 

关键词: CANNABINOID RECEPTOR;    DOPAMINE D3 RECEPTOR;    PREMENSTRUAL SYNDROME;    GENETIC POLYMORPHISM;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women.Objective: The aim of this study was to investigate the association of Dopamine D3 receptor (DRD3) polymorphism, and Cannabinoid receptor Type 1 (CNR1) polymorphism with PMDD.Materials and Methods: Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method.Results: Distribution of DRD3 and CNR1 polymorphism was not different between patients and controls.Conclusion: These findings do not support a major role of DRD3, and CNR1 polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.

【 授权许可】

Unknown