CABERGOLINE PLUS METFORMIN THERAPY EFFECTS ON MENSTRUAL IRREGULARITY AND ANDROGEN SYSTEM IN POLYCYSTIC OVARY SYNDROME WOMEN WITH HYPERPROLACTINEMIA

Iranian journal of reproductive medicine

JOWKAR AKRAM¹  GHANEEI AZAM¹  HASANI GHAVAM MOHAMMAD REZA¹  GHANEI MOHAMMAD EBRAHIM¹ 

关键词: POLYCYSTIC OVARIAN SYNDROME;    CABERGOLINE;    METFORMIN;    MENSTRUAL CYCLE;    LABORATORY FINDINGS;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: 30% of patients with polycystic ovary syndrome (PCOS) show mild, transient hyperprolactinemia. It is suggested that a reduction of the dopamine inhibitory effect might raise both prolactin and luteinizing hormone.Objective: To investigate the adjuvant cabergoline therapy effects on menstrual irregularity and androgen system in PCOS women with hyperprolactinemia.Materials and Methods: This randomized clinical trial was done on 110 polycysticovary syndrome women with increased serum prolactin concentration [1.5 fold morethan normal level (>37.5 ng/ml)]. Participants were divided into two groups: Casegroup (n=55) treated with metformin 1gr/day and cabergoline 0.5 mg/week for 4months and control group (n=55) treated with metformin 1g/day and placeboweekly. Testosterone, prolactin, and dehydroepiandrosterone sulfate level weremeasured before and four months after intervention in two groups. Also, situation ofmenstrual cycles asked and recorded before and after intervention.Results: We found decrease in the mean of dehydroepiandrosterone sulfate, weightand total testosterone level in the two groups after intervention but their changeswere not significant. Patients in case group showed a significant decrease in serumprolactin level before and after intervention (p<0.001), but no difference was foundin control group. All patients in both studied groups had irregular menstrual cycles, which regulate after intervention and the difference was significant (p=0.02).Conclusion: The results showed that cabergoline can be used as a safe administration in PCOS patients with hyperprolactinemia to improve the menstrual cycles. Considering that the administration of cabergoline plus metformin may reduce the required duration and dose of metformin, patient acceptability of this approach is higher.

【 授权许可】

Unknown