PREDICTION OF CLINICAL PREGNANCY IN VITRIFIED-WARMED SINGLE BLASTOCYST TRANSFER CYCLES BY PRE-FREEZE MORPHOLOGY

Iranian journal of reproductive medicine

WANG HAIQING¹  ZHENG YI¹  WU YONGGEN¹  LI YAN¹  HUANG XUEFENG¹  XIAO SHIQUAN¹  ZHOU YING¹  ZHANG HUAN¹ 

关键词: IN VITRO FERTILIZATION;    INNER CELL MASS;    BLASTOCYST;    VITRIFICATION;    MORPHOLOGY;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: The selection of blastocyst warmed for transfer is based on pre-freeze morphology in vitrified-warmed single blastocyst transfer cycles. But, it is controversial which parameter of blastocyst morphology most closely related to the clinical outcomes.Objective: To estimate the effect of blastocoele expansion, trophectoderm (TE) morphology grade, and inner cell mass (ICM) morphology grade on clinical pregnancy in vitrified-warmed single blastocyst transfers.Materials and Methods: There were 172 vitrified-warmed single blastocyst transfer cycles during the year 2012 included in this analysis. Comparison of clinical results between pregnancy and no pregnancy group based on patient and blastocyst morphology characteristics was done. Then stepwise logistic regression analysis was used to select the best morphological predictor for clinical pregnancy. Last, comparison of patient characteristics and clinical outcomes separated by the best independent morphological predictor was done.Results: Comparison of clinical results between pregnancy and no pregnancy group and logistic regression showed the clinical pregnancy rate was affected by ICM. Comparison of patient characteristics separated by ICM grade, ICM grade A cycles got higher clinical pregnancy rate than ICM grade B cycles (54.3% vs. 35.0% respectively, p=0.037).Conclusion: Blastocyst with good ICM morphology could increase clinical pregnancy rate in vitrified-warmed single blastocyst transfer cycles.

【 授权许可】

Unknown