EFFECTS OF GLYCOWITHANOLIDES ON LIPID PEROXIDATION AND LIPOFUSCINOGENESIS IN MALE REPRODUCTIVE ORGANS OF MICE

Iranian journal of reproductive medicine

SARVALKAR PRITI¹  WALVEKAR MADHURI¹  SHAIKH NILOFAR¹ 

关键词: WITHANIA SOMNIFERA;    ANTIOXIDANT;    LIPID PEROXIDATION;    CYTOPLASMIC GRANULES;    TESTES;    EPIDIDYMIS;    SEMINAL VESICLE;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Glycowithanolides (Withaferin A), is one of the main withanolides active principle isolated from plant Withania somnifera and is claimed that it possess the aphrodisiac, sedative, rejuvenate and life prolonging properties.Objective: In the present investigation, antioxidant activity of active principles of Withania somnifera was tested against D-galactose induced oxidative stress in mouse testes, epididymis and seminal vesicle.Materials and Methods: For the present investigation Swiss male albino mice Mus musculus (Linn) were used. They were grouped in to control (I), D-galactose treated (II), protective (III) and curative groups (IV). Oxidative stress was induced in six month old mice by injecting a low dose of D-galactose. Antioxidant effect of plant extract was studied in testes, epididymis, and seminal vesicle of oxidative stressed mice on Lipid peroxidation (LPO) and fluorescence product.Results: In the present study, both total as well as mitochondrial lipid peroxidation and fluorescence product in testes, epididymis and seminal vesicle were increased in D-galactose induced mice. After the treatment of glycowithanolides there was significantly decrease in total as well as mitochondrial lipid peroxidation and fluorescence product in protective and curative groups.Conclusion: Our results indicate that Withania somnifera has a capability of preventing oxidative stress and also combating stress induced infertility.

【 授权许可】

Unknown