HISTOLOGICAL CHANGES IN TESTES OF RATS TREATED WITH TESTOSTERONE, NANDROLONE, AND STANOZOLOL

Iranian journal of reproductive medicine

MOHD ALI AISHAH¹  SURINDAR SINGH GURMEET KAUR¹  HUSSIN SITI NOORAISHAH¹  MANI VASUDEVAN¹  MOHAMAD MASHANI¹  MOHD MUTALIP SITI SYAIRAH¹ 

关键词: TESTOSTERONE;    NANDROLONE;    STANOZOLOL;    TESTES;    SUBSTANCE ABUSE;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Anabolic androgenic steroids (AAS) is being used in medical treatments, but AAS also was identified to have the risks of adverse effects towards patients and consumers health. Objective: Present study was conducted to observe the effects of testosterone, nandrolone, and stanozolol (forms of AAS) intake during onset of puberty on the rat testicular histology.Materials and Methods: Juvenile male Sprague-Dawley (SD) rats (n=42) were divided into seven groups and were injected subcutaneously with medium dose of polyethylene glycol-200 (PEG-200) (control), testosterone, nandrolone, and stanozolol for six weeks (PND 41-87). The animals were weighed daily and sacrificed on PND 88. Testes were removed, weighed, and prepared for histological assessment and finally specimens were observed under microscope.Results: The results showed an insignificant increase in mean daily body weight with highest and lowest body weight gained was of 177.6±1.69 gr and 140.0±12.26 gr respectively. There was significant decrease in the testes absolute weight (p?0.01) in all experimental groups except in the nandrolone 2.5 mg/kg/week treated group. Testicular histology of rats treated with AAS also showed slight changes in the uniformity of arrangements of seminiferous tubules.Conclusion: Data from present study suggests that AAS have been initiating the adverse effects on testicular normal functions in rats during onset of puberty.

【 授权许可】

Unknown